In Once Human, your choice of gear and weapons significantly impacts your effectiveness in combat. Whether you're battling corrupted beasts in PvE zones or launching raids on player settlements in PvP, a well-optimized build can be the key to your survival and success.
This comprehensive guide delves into four of the most potent builds available in the latest version of Once Human. It includes detailed insights on weapons, gear modifications, synergy effects, and strategic playstyle tips. From builds designed for area-of-effect (AoE) clearing to those focused on damage-over-time (DoT) and critical burst damage, each setup has been rigorously tested for both solo and team scenarios.
If you're just starting out, don't miss our Beginner’s Guide for Once Human to get a thorough introduction to the game!

Final Tips for Optimizing Your Build
- Sync weapon effects and mods: Select gear that complements your weapon’s elemental or status effects to maximize your impact in battle.
- Keep upgrading: The rarity and enhancement level of your gear play a crucial role in boosting its effectiveness. Always stay updated with the latest enhancements.
- Craft backup loadouts: Having an alternative build based on different elements can be vital for adapting to various mutant types or countering PvP opponents effectively.
Each build in Once Human is tailored for specific scenarios, whether it's tackling boss fights, clearing waves, or executing quick PvP takedowns. It's essential to experiment with different loadouts, fine-tune your gear mods, and switch builds based on the mission type or the enemy's resistance profile.
For the ultimate gaming experience—featuring lag-free aiming, multi-instance farming, and swift inventory management—consider playing Once Human on BlueStacks. This platform enhances your gameplay with full control support and ultra-smooth frame rates.