Bringing a super-sized canine back from extinction after 12,500 years might sound like a plot from a blockbuster movie, complete with special effects of gnawed flesh and buckets of fake intestines. However, it's a reality thanks to the efforts of Colossal Biosciences, a biotech company that has successfully revived three dire wolves. These majestic creatures, named Romulus, Remus, and Khaleesi, reside in a secret location within the US.
Romulus and Remus at three months old
Colossal Biosciences utilized DNA from the common gray wolf, advanced gene-editing techniques, and domestic dog surrogates to bring these dire wolves to life. The result is a trio of huge, white, awe-inspiring animals that would make any mother of dragons proud.
“I could not be more proud of the team. This massive milestone is the first of many coming examples demonstrating that our end-to-end de-extinction technology stack works,” stated Ben Lamm, CEO of Colossal.
“Our team took DNA from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies. It was once said, ‘any sufficiently advanced technology is indistinguishable from magic.’ Today, our team gets to unveil some of the magic they are working on and its broader impact on conservation.”
Romulus and Remus at one month old
This isn't the first time Colossal Biosciences has captured headlines. They previously engineered a "Colossal Woolly Mouse," resembling a mammoth phenotype, using computational analysis of 59 woolly, Columbian, and steppe mammoth genomes ranging from 3,500 to over 1,200,000 years old. Critics argue that the dire wolves are essentially normal wolves in fancy dress, suggesting that the dire wolf DNA used is insufficient for a true genetic clone.
Colossal Biosciences' ambitions extend beyond creating social media sensations or owning extraordinary pets. The company aims to apply their findings to preserve current species for future generations.
“The de-extinction of the dire wolf and an end-to-end system for de-extinction is transformative and heralds an entirely new era of human stewardship of life,” explained Dr. Christopher Mason, a scientific advisor and member of the board of observers for Colossal.
“The same technologies that created the dire wolf can directly help save a variety of other endangered animals as well. This is an extraordinary technological leap in genetic engineering efforts for both science and for conservation as well as preservation of life, and a wonderful example of the power of biotechnology to protect species, both extant and extinct.”
To ensure the well-being of these dire wolves, Colossal Biosciences has collaborated with the American Humane Society and the USDA to establish a 2,000+ acre preserve as their home. The wolves are cared for by a dedicated team, ensuring they live comfortably and healthily.